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There are lot of medical uses where Botox has been used but since it's only been around since mid-90s, we do not yet know its long-term effects or its full potential.

Advertisers often look at lists sizes first, instead of looking at open rates for a newsletter. For example, they would be more willing to support someone with 50,000 subscribers than someone with 13,000, even if the latter gets 2-3x more people to actually open the newsletter. Size matters.

It makes sense to get a management company once you've streamlined your product offering and can use them to amplify your growth.

Anger can motivate us to respond to injustice. There are various ways to fix a problem. We have to get mad first, then channel that anger into fighting back, which doesn’t have to be with aggression or hostility.

Despite the depression, 1930s saw a boom in innovation and growth, riding on the tailwind of scientific and and technological innovation from the 1920s. Aviation, plastics, movies, appliances, and a bunch of other industries got going in that time. By 1939 three-times as many people had cars in US as they did in 1929. It all got badly mismanaged, but the basis for a booming economy were all there. Today, on the other hand, we are doing a fine job managing the economy, but we don't have such a strong tailwind to propel our growth.

Techniques that have been used aren't powerful enough to do the type of learning that humans do. The people who do most of that learning are babies and young children.

You’ve got to go with your gut. You can’t overanalyze things because if you do, you’ll lose that opportunity when you are consumed with worry.

Dan Mall does it like this -- Nine months total. First three months are completely unpaid, focused on learning. Next three months are paid, focused on practicing those skills on low-risk tasks. Last month, apprentices work on their master projects and look for their next gig. Dan does not employ them, but he helps to enable their next adventure.

Joel speculates that many people like him are often living with an imposter syndrome, constantly prioritising work over their personal needs, be that health or family.

Before working at Google he spent two years working for a startup, spending every waking moment living and breathing the needs of that company. One would think that joining Google would be easy, and allow Joel to rest, but even then, he's always feeling like he is not doing things fast enough.

The founders did not want to waste time building products, so instead they spun out 12 different landing pages and launched them all, measuring which one gathered the most interest. Parse won.

Don't make it more complicated than it has to be. Figure out a need, and find a way to solve it. Your business might not be sexy, and it's going to be hard work, but it will make money. The hard part is all emotion. Hard part is making cold calls, being rejected, putting yourself on the line.

Start simple, get your first customers, and then look for more opportunities from there on.