Ever wonder how we poop? Learn about the gut -- the system where digestion (and a whole lot more) happens -- as doctor and author Giulia Enders takes us inside the complex, fascinating science behind it, including its connection to mental health. It turns out, looking closer at something we might shy away from can leave us feeling more fearless and appreciative of ourselves.

The wait is finally over: this week we are very excited to bring you the episode we’ve been teasing for weeks: vaccines! This week and next (you don’t have to wait a full two weeks for the next episode!), we are presenting a two-part series on vaccines. In today’s episode, we dive deep into the biology of vaccines, from how they stimulate your (amazing) immune system to protect you, to how they make you into an almost-superhero, shielding the innocents around you from deadly infections. We take you back hundreds, nay, thousands of years to when something akin to vaccination first began, and then we walk along the long road of vaccine development to see just how massive an impact vaccines have had on the modern world. The best part? We are joined by not one, but two experts from the Bill and Melinda Gates Foundation. Dr. Gail Rodgers and Dr. Padmini Srikantiah explain the process of vaccine development, highlight the challenges of vaccine deployment, and shine a hopeful light on the future of vaccines. And be sure to tune in next week for part 2 where we’ll focus on vaccine hesitancy and address common misconceptions surrounding vaccines in even more depth.

For more information on the Bill and Melinda Gates Foundation initiatives, visit: https://www.gatesfoundation.org/

For more information on vaccines currently in development, check out: https://clinicaltrials.gov/ and https://www.who.int/immunization/research/vaccine_pipeline_tracker_spreadsheet/en/

And, as always, you can find all of the sources we used in this episode on our website: http://thispodcastwillkillyou.com/episodes/

Mark Cuban is a serial entrepreneur, investor, and owner of the Dallas Mavericks. His career began with his founding of MicroSolutions, a company he went on to sell to CompuServe in 1990. Then in 1995 Mark co-founded Broadcast.com - streaming audio over the internet. In just four short years, Broadcast.com (then Audionet) was sold to Yahoo for $5.6 billion dollars. Following the acquisition in 2000, Mark acquired the Dallas Mavericks where since his taking over they have competed in the NBA Finals for the first time in franchise history in 2006 - and becoming NBA World Champions in 2011. They are currently listed as one of Forbes' most valuable franchises in sports. If that was not enough, Mark is also one of ABC's "Sharks" on the hit show Shark Tank.

Dave Bowen is the CEO of Purchasing Platform, an online marketplace for real estate developers to buy products for their properties. Before Purchasing Platform, Dave was the founder of Market Maker 4 (MM4), an e-sourcing tech startup, which he bootstrapped and sold for $22M in 2016. In this episode he talks about the pros and cons of bootstrapping a business, how to run a two-sided marketplace, and the pains and strategies for B2B sales.

In 2015, Scott Jurek was the most talked about person on the Appalachian Trail, even the trail community at large.  As soon as the legendary ultrarunner announced that he was bringing his talents to Appalachia, a flurry of fanfare and press...

On this episode Ryan is joined by Joel Gascoigne, CEO of Buffer, a simple tool manage all your social media accounts. We've been avid users, big fans, and paying customers for years.

In this episode Ryan and Joel talk about...

* Joel's roundabout journey from the UK to the US via Hong Kong and Israel.

* What it's like to manage an 85-person completely distributed team.

* Buffer's extreme transparency and how that endears the company to its customers.

* Why (in a very unorthodox move) Buffer bought out their investors last year.

Of course, Joel also talks about some of his favorite products as well.

We’ll be back next week so be sure to subscribe wherever you listen to your favorite podcasts. Big thanks to Pilot and Monday.com for their support. 😸

Galen Ward is a CEO of a tech company and a father of two awesome girls. Listen and learn how to share the labor of parenting with your partner and how to set your kids up for success from the young age.

Roberto from the Expeditioners is the dad many wish they could be. Instead of holding a steady job, he and his family are busy traveling the world, taking gorgeous photos for brands that pay for his living. Roberto is fit and happy, and is not concerned with the norm. Find out what it takes to be a self-made entrepreneur, and how to be paid to be happy.

Following Mark Zuckerberg's big encryption pivot for Facebook, David, Joanna and Christopher unpack the privacy talk. Reporter Katie Bindley comes in to share her own stories of Facebook's creepy ad behavior, then David interviews Frank Yang, CEO of Simplehuman, about why talking trashcans are people too. The Weekly Upgrade: Christopher solves your ducking autocorrect problem.