Mark Cuban

Mark Cuban says doctors should not be replaced, and he does not think they ever will be. A person who tries a new personalized medicine and gets sick still needs a human in the room, with all five senses, who can see a crying parent or child and add that to the context. A video or a robot is behind the moment. The model has latency, and someone still has to know which questions to ask and which variables matter.

Julie Yoo says abundant care advice will make more people demand a real visit, so the country will need more doctors, and the work can look more like a physician-scientist dealing with data that exists for one person and not yet for a population. Mark Cuban says the sharp change is

Mark Cuban says the cost of designing a drug for one person, after a model reviews that person's DNA, will start approaching zero as models get more capable. Faster chips, power, and networks matter, but the algorithms are what change the price, and nobody yet knows how fast the algorithms improve. He puts the shift at five, ten, or twenty years.

The first drugs are the ones on a drugstore shelf. Advil, Tylenol, and ibuprofen are not the same drug in every body, and people find out by trying them. Once a model can personalize an over-the-counter dose, the same logic reaches prescription drugs where patients now choose among Eliquis, Xarelto, and warfarin. He told two frontier labs to fold t

Mark Cuban says there will be the trillionaire in the basement, and that there is no better time to be an entrepreneur than right now. Somebody will put out an agent swarm and do it on an entrepreneurial basis.

Agents are the hard part of that picture. They do not see social media posts and cannot review them. Transcripts for any real number of posts are hard to get, and agents cannot watch ads or see ads. If individuals move to an agent-driven economy, a lot has to change in how commerce is communicated to the agents. The fortune he describes sits in that gap: one person, a swarm of agents, and a business that does not exist yet.

Mark Cuban tells employers to run every benefits contract through AI before they sign it. That includes the broker, the consultant, the third-party administrator, and the pharmacy benefit manager. The prompt asks one question: where the other side is ripping the employer off, and what to do about it. He says the problems show up in about 30 seconds.

He gets the contracts by sending agents after public records, requests for proposals, and similar files from states, cities, school districts, and unions. The request letters land in his email drafts. The files go to a Google Drive his models can read, and he asks each model for the good news, the bad news, and a short version he can send back.

Mark Cuban says there will be two types of companies: companies great at AI, and companies that have gone out of business. People split the same way. Some use AI to learn anything. Others use AI so they do not have to learn anything.

Asked where no one is building, the answer is all of them. The same advice is for kids and for 50-year-old, 60-year-old, and 70-year-old entrepreneurs. Take the time to learn AI, spot the companies and problems AI is not solving, and talk to an AI by voice or by typing. Comfort with talking to an AI is the biggest challenge for entrepreneurs using AI, and a lot of hesitancy remains. With the first spreadsheets, people still had a 10-key adding machine and would

Mark Cuban says a nonprofit hospital financial assistance plan is a program every nonprofit hospital has to have, and consumers get the greatest benefit when they learn it before anything happens. 40% of people in the country cannot afford a $400 emergency bill. Some of the programs are really good.

The move before anything happens is to open a favorite AI model and ask for a list of all the nonprofit hospitals, then ask the hospitals what financial support services they offer. In most cases pricing is a reference price tied to federal poverty levels, but it can go up to 600% of the federal poverty level, which can be over $100,000 for some families in some states. For some people, the insu

Mark Cuban built agentfeeds.dev with one of the guys at his company so an agent can take in social-post transcripts and ad information it cannot see on its own. The site is not truly active.

Agents do not see social media posts and cannot review them. Transcripts for any material amount of posts are hard to get, and agents cannot watch ads or see ads. If individuals move to an agent-driven economy, a lot has to change in how commerce is communicated to agents. A person puts the transcript of posts into agentfeeds.dev and copies and pastes it. Anyone can paste people they follow into their agents, tell the agent to follow all the feeds, and the tool takes all the ads and supplies the informa

Mark Cuban says the healthcare workforce looks the same as any other industry, and AI does not replace jobs. People who know how to use AI replace the jobs of people who do not know how to use AI.

Over the next five years, companies still have to hire entry-level people. The minute a model is released, it is already behind, and every model has latency. New hires stay aware of what is going on, create context, act as the human in the loop, and understand the consequences. They grow with the organization and carry the history of each implementation. The same enablement has to reach the rest of the white-collar staff. The larger step is teaching the C-suite how AI works: how agents work, how t

Mark Cuban says Cost Plus Drugs can make tableted generic drugs in Dallas, Texas for less than it pays partner manufacturers in India, using manufacturing pods that sell for $20 million each. The mission is to disrupt healthcare so it is affordable again. He supports universal healthcare, but correct data has to come first so people can decide from real numbers. Trust is the primary product. Cost Plus Drugs spends nothing on marketing or advertising, keeps a set markup of 15%, and stays fully transparent so people tell others how much money they saved, even if a rival offers cost plus 1%.

Within two years he expects sales of a couple hundred pods a year, and within five years a couple thous

Mark Cuban launched CostPlusDrugs.com on January 19, 2022 with 111 generic medications and no idea what demand would look like. Talking about the site made it blow up, manufacturers widened their portfolios, and the catalog now holds about 4,000 products, with the business up and to the right every week. The hardest job is keeping up.

Same-day pickup needed a second offer, TeamCubanCard.com, a discount card Mark Cuban says he did not name. It works at 17,000 affiliated pharmacies. Affiliate pharmacies get a $12 fill fee, so a $5 statin plus $12 is cheaper somewhere else, though buyers can still use an independent pharmacy for the cheap drugs. Specialty generics and biosimilars are much chea

Mark Cuban says the United States could get into a debt bubble because hyperscalers are borrowing so much.

The federal deficit keeps rising, so the country has to borrow more, and the hyperscalers are borrowing more than they make. Lenders then compete for that business and rates rise. He says a company with a $40 billion debt can reach a point where it cannot raise money anymore. NVIDIA, he says, is subsidizing half the industry because it has the cash, and Meta is borrowing more than it has in cash flow. Until the spending looks like brilliance, he says, private credit stays uncertain and a lot can go wrong. He cites Ray Dalio, who says the country has already crossed the curve toward a d

Mark Cuban says the real money is made in a bear market, when prices turn and a buyer has cash ready.

He points to Charlie Munger and Warren Buffett, who he says would go a couple of years without investing at all, and he has tried to do the same. During COVID he started buying as the market fell, and he says he crushed it. He says AI-related stocks are going to the moon, with a lot of debt behind the move, and the approach now is patience: invest a little for fun, hold cash, and wait. When the run turns, he says, that is when the real magic happens and the real money is made.

Mark Cuban says get-rich-quick schemes spread on social media because each person sees more of whatever they already watch.

His son, who just turned 17, kept showing him dropshipping, shoe drops, and a water blaster for cleaning sidewalks. Mark Cuban says if the schemes were good businesses, the people behind them would be running the businesses, and nobody with an edge in the stock market would be selling that edge. He says Section 230, which protects algorithms, is a big part of holding kids back, because preparation does not earn views on Instagram or TikTok. A 10-second clip, seen enough times, starts to feel true.

Steven Bartlett says the opposite move is a long time horizon: preparat

Mark Cuban sold the Dallas Mavericks for $4.3 billion after buying the team for $285 million.

He bought it right after he made his money. He was a season-ticket holder who thought it would be fun to shoot baskets with Dirk Nowitzki, Steve Nash, or Michael Finley, not a 25-year business plan. The team had been voted the worst professional sports franchise of the previous decade, and his goal was to turn it into a winner. A loss could take him two days to get over. Later the league talk shifted from making the game better to what the teams were worth, and competing required real estate skill that had nothing to do with basketball. He had not planned to sell. Having kids changed that. Steven B

Mark Cuban's goal is to change healthcare in the country so healthcare is truly a right. He says that means the big companies can no longer dominate the industry.

He goes door to door with chief executives and pushes them hard. If he can get them to do the right thing, save themselves money, and improve the health of their employees and families, he calls that a win and a way to completely change healthcare in the country. Steven Bartlett brings up a rollercoaster relationship with Trump and says he saw Mark Cuban stand next to Trump talking about the initiative. Mark Cuban says anything that makes people healthier and saves them money on healthcare is fine by him. He says criticism does no

Mark Cuban says his kids and his wife supersede everything else. Nothing is more important to him, and they have changed him for the better in a million ways he cannot even describe. One part of his mind stays on business and on competing. The better part of him is his kids and his wife.

He married in 2002, when he was 44, and he has three kids. Steven Bartlett asked whether family and business could have happened at the same time. Mark Cuban says he would not have done both as well as he did the business. When he had Micro Solutions he was on a mission and did not put family in front of business. He regrets that he did not do as many of the little events with his kids as he probably should

Mark Cuban says money changed his life and did not change his life. It covered the things he could buy and removed the stress of where he lived and of paying the bills. It did not make him a better person or a worse person, and it did not change his relationship. Being a celebrity was a lot harder than being rich.

Steven Bartlett asked if that was really true, and Mark Cuban said yes, particularly once social media became more prevalent. Shark Tank blew up and sat at peak ratings at the same time the Mavs had just won a championship, and strangers treated him as a celebrity, saying Shark Tank was a new favorite show. He says being rich does not give you attention. It only changes how you de

Mark Cuban says money cannot change who you are. If you are miserable when you are poor, there is a good chance you are going to be miserable when you are rich. Money cannot change your approach to life. Money cannot change how you feel about yourself. It really will not.

Steven Bartlett asked what acquiring lots of money had taught Mark Cuban about happiness and what life is really about. Mark Cuban says it is nice. He likes being rich a whole lot more than he likes being broke. He takes pride in the fact that he still has the same friends. His high school buddies are still his high school buddies. He is still close to his brothers. He is still close to his rugby teammates. He is still clo

Mark Cuban says something has got to give if interest rates go to 6 percent, 8 percent, or 10 percent. At current interest rates, the country is paying a trillion dollars in interest every year.

If interest rates keep going up, if what the country has to borrow keeps going up, and if hyperscalers keep competing to get access to the money, something gets crowded out. Mark Cuban says he does not know which part breaks because he is not enough of a financial expert, and he still says something is going to give. Steven Bartlett asks whether Mark Cuban is playing defense just in case. Mark Cuban says yes. He has money in more than one country, and he has not invested nearly as much. He calls the

Mark Cuban says AI is not smart because it is only book smart. Book smart means a person who can read a book, remember what is in it, and get A's on tests by memorizing everything. Smart means aggregating information and inputs, knowing where to look for the inputs, taking them, and identifying the problem you are trying to solve. AI does not do that.

He says you have to be in real time. During the conversation he did not know which questions Steven Bartlett would ask, and AI is missing all of that. There is no way to feed AI everything humans have access to. If he is a doctor and Steven Bartlett is there, access to every research report and article speeds the visit up. Then Steven Bartlett