Smash Notes

Back to Andrew Huberman - The Frontier of Neurotechnology, with Andrew Huberman.

Why Are Waking Brain States the Next Problem in Neuroscience?

Andrew Huberman says waking brain states are the most important thing to resolve right now, and that the work is doable. Sleep already has names: slow-wave sleep, deep sleep, and stages N1, N2, and N3. A chapter of his book Protocols covers that architecture, including how warming the bed or the room in the morning brings more REM. He says eye-mask tools might even dial sleep in more precisely than changing the room temperature. None of that vocabulary describes a person who is awake.

He cannot name the state of the interview beyond alert, focused, and enjoying the discussion. REM is a label for rapid eye movements, not for how the state feels. The missing map is which waking states fit which activities. Once that map exists, writing to the nervous system could generate the states with temporal and spatial precision. He is not the person who will build it. He no longer runs a lab.

Transcript

Andrew Huberman - The Frontier of Neurotechnology ·

Invest Like the Best with Patrick O'Shaughnessy

More from this episode

  1. How Does Andrew Huberman Feel on Seven Hours of Sleep?Andrew Huberman feels great on seven hours of sleep. Eight hours probably puts him into the day a little groggy. Six hours he can manage just fine.
  2. Why Does Heart Rate Have to Drop Before Sleep?Andrew Huberman says thoughts do not actually turn off until heart rate drops.
  3. Why Does Rocking Put People to Sleep Faster?Andrew Huberman says rocking puts people to sleep faster because side-to-side motion makes the eyes generate compensatory movements under closed lids, and the…
  4. What Is the Biggest Problem in Neuroscience?Andrew Huberman says the biggest problem in neuroscience is also the one he finds coolest: how to write to the nervous system without opening the skull, in…
  5. Why Will AI Companies Become Biotech Companies?Andrew Huberman says Meta, OpenAI, and Anthropic are each going to be a biotech company, and that Elon's stated neural interest is Neuralink.
  6. Why Do People Think the Vagus Nerve Only Calms You Down?Andrew Huberman says people picture vagus nerve stimulation as a way to calm down, while most vagal pathways are excited by that stimulation and the effect he…
  7. Why Do High Glucagon-like Peptide Doses Dull Drive?Andrew Huberman says ramping GLP levels up a thousandfold leaves people less hungry, and past a certain level they are less driven for other things too.
  8. Why Do Some Doctors Fear Whole Body Scans?Andrew Huberman posted on X a few weeks ago that if the cost of a whole body MRI comes down, he can imagine most people would want one.
  9. How Does Psilocybin Form New Brain Associations?Andrew Huberman says psilocybin increases serotonin massively, unmasks lateral connections in the brain, and allows new associations in a very condensed…
  10. Why Are Technologists Becoming Neuroscientists?Andrew Huberman says the technologists who used to only engineer things are becoming neuroscientists, and that the field has always gained when people arrive…

People

More answers like this

The other side

More with Andrew Huberman

Related episodes

Plays from this note through the rest of the episode.

Weekly highlights

One letter a week.

The notes worth hearing, with the minute they were said.