Why Do High Glucagon-like Peptide Doses Dull Drive?

Andrew Huberman says ramping GLP levels up a thousandfold leaves people less hungry, and past a certain level they are less driven for other things too.

The hypothalamus holds deep circuits that control hunger, anger, sexual appetite or the lack of it, and hormone secretion. The circuits work as switches. Science understands the switches, and science does not understand every part of them. GLPs gained so much velocity because scientists know where they bind in the brain. They bind in the hypothalamus and in other areas, turning on neurons that suppress appetite. The equation is simple: raise GLP levels a thousandfold and hunger drops. Push past a certain level and drive for other things drops as well.

He thinks Sam Altman talked about that experience and about deciding either to back off the dosage or to stop taking the drugs.